BDBM50122758 2-methyl-4-(pyridin-3-ylethynyl)thiazole::3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine::3-(2-Methyl-thiazol-4-ylethynyl)-pyridine::3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine::3-[(2-methyl-4-thiazolyl)ethynyl]pyridine::CHEMBL292065::MTEP

SMILES Cc1nc(cs1)C#Cc1cccnc1

InChI Key InChIKey=NRBNGHCYDWUVLC-UHFFFAOYSA-N

Data  19 KI  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50122758   

TargetMetabotropic glutamate receptor 1(RAT)
Recordati

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Recordati

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Recordati

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]R214127 from rat cloned mGluR1 receptor expressed in CHO-T-Rex cells after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Affinity DataIC50: >1.00E+5nMAssay Description:Tested for in vitro antagonistic activity against Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed